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Pratley, MD, Medical Director at the AdventHealth Diabetes Institute Orlando, FL, and Co-Chair of the FLOW Trial

This gradual approach is important

The studys primary endpoints were changes from baseline in glycated hemoglobin (HbA1c, a marker of long-term blood sugar levels) and total body weight at 182.5 days and 365 days post-initiation

Serious but rare side effects: Acute pancreatitis (severe abdominal pain) Gallstones Allergic reactions (rash, swelling, difficulty breathing) Monitor for signs of dehydration due to gastrointestinal side effects

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Small shifts in channel gating can lead to arrhythmias, hypertension, or heart failure